Omega-3 index: what it is, what it tells you and when it’s tested
The omega-3 index shows what share of the fats in your red blood cells is EPA and DHA, the two omega-3s from fish. It is given as a percentage. It reflects what you have eaten over the last few months, not just the last few days.
When it’s tested
GPs do not usually order it: it is asked for by people who want to know whether they eat enough fish, or by a doctor or dietitian following someone who takes supplements. Only a few specialised labs run it.
It is not a routine test. In studies, people with a higher index live longer on average and have less heart disease. But taking omega-3 supplements has had little or no effect on heart attacks and deaths. That is why the result rarely changes care.
That is why Rosa does not test it. Instead it looks at triglycerides, ApoB, LDL cholesterol and high-sensitivity CRP, which say more about your heart risk. Triglycerides are also the value omega-3s lower most.
What it tells you, and what it does not
It tells you how much EPA and DHA you have taken in over the last few months, from fish or supplements. It is steadier than omega-3s measured in plasma, which change with your last meal.
It does not say whether you have heart disease, or how high your risk is. Cholesterol, blood pressure, smoking and blood sugar answer that.
That is why it is read together with other tests:
- Triglycerides: Omega-3s lower them
- ApoB: It counts the particles that carry cholesterol into arteries
- LDL cholesterol: The first value for heart risk
- High-sensitivity CRP: It shows background inflammation
Omega-3 index reference values
There is no range printed on every lab report, as there is for other tests. The thresholds from studies are used: up to 4% is low, and 8% or more is the level that studies link to the lowest heart risk.
Each lab uses its own method. To compare two results, use the same lab.
There is no established upper limit. But getting there with high-dose supplements has its own risks.
What your result means
Find the row for your result, as a percentage.
- Up to 4: Low. In studies, people at this level have on average the highest heart risk. It usually means little oily fish in the diet. More oily fish helps. If you are thinking of a supplement, ask your doctor.
- Above 4, below 8: Intermediate. A middle zone: the protection seen in studies is intermediate, and there is room to rise. Eating oily fish regularly is the simplest way to raise it.
- 8 or more: High. In studies, people at this level have on average the lowest heart risk. Nothing to do. If you get here with high-dose supplements, talk to your doctor.
If your omega-3 index is low or high
- Low omega-3 index: Usually little oily fish. It rises if you eat more, over a few months.
- High omega-3 index: Often a lot of fish or supplements. That is fine, but with high-dose supplements talk to your doctor.
Omega-3 supplements: what studies say
Supplements raise the omega-3 index and lower triglycerides. On heart attacks, strokes and deaths taken together, though, the effect in trials has been small or none. There may be a small benefit for coronary heart disease.
At high doses they raise the risk of atrial fibrillation, an irregular heartbeat. The higher the dose, the higher the risk.
If you are thinking of a supplement, or already take blood thinners, ask your doctor whether you need it and how much.
How to raise your omega-3 index
The simplest way is through your plate:
- Eat oily fish regularly, such as sardines, anchovies, mackerel, herring or salmon.
- The value rises slowly: red blood cells renew over a few months. Retesting sooner makes little sense.
- If you eat little or no fish and are thinking of a supplement, decide it with your doctor.
What can skew the result
The omega-3 index is stable, but a few things matter.
- The lab’s method: Each lab analyses fats in its own way. To compare two results, use the same lab.
- A recent change in diet: If you have only just started eating more fish or a supplement, the value has not fully risen yet.
When to worry
The omega-3 index on its own is not a reason to see a doctor. Talk to your doctor if:
- It is low and you are thinking of taking a supplement.
- You take high-dose omega-3 and feel your heart beating irregularly.
- You take blood thinners or antiplatelet medicines and want to add omega-3.
- You have chest pain, fainting or a very fast, irregular heartbeat with shortness of breath: call 112 or go to the emergency department.
Frequently asked questions
What is the omega-3 index? It is the percentage of EPA and DHA, the omega-3s from fish, among all the fats in your red blood cells. It reflects the last few months of eating.
What is a good omega-3 index? In studies, up to 4% goes with the highest heart risk and 8% or more with the lowest. There is no established upper limit.
Where can I get an omega-3 index test? Not at every lab. Only some specialised labs offer it: ask your lab or your doctor.
Do omega-3 supplements help? They raise the index and lower triglycerides, but in trials they did little for heart attacks and deaths. At high doses they raise the risk of atrial fibrillation. Decide with your doctor.
Does Rosa test the omega-3 index? No. Rosa measures triglycerides, ApoB, LDL cholesterol and high-sensitivity CRP, which say more about your heart risk.
Sources
- Harris and von Schacky, the Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine, 2004. PMID 15208005
- Harris and colleagues, FORCE consortium, blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nature Communications, 2021. PMID 33888689
- Abdelhamid and colleagues, omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, 2020. PMID 32114706
- Gencer and colleagues, effect of long-term marine omega-3 fatty acids supplementation on the risk of atrial fibrillation: a systematic review and meta-analysis. Circulation, 2021. PMID 34612056