HDL cholesterol: what it is, what it tells you and why we test it
HDL cholesterol is what many people call good cholesterol. It takes extra cholesterol out of your artery walls and carries it back to your liver. A low level is a signal worth understanding, and it often comes with high triglycerides and too little exercise.
Why we test it
HDL makes the opposite trip to LDL. LDL carries cholesterol out to your tissues and, if it stays high for years, leaves it in your arteries. HDL brings some of it back to your liver.
A low HDL is linked to a higher risk for your heart. And it rarely comes alone: high triglycerides, fat around the belly and a body that struggles to use sugar often come with it.
You cannot feel any of this: only a blood test shows it.
What it tells you, and what it does not
If it is low, it usually says something about your habits or your metabolism: too little exercise, smoking, a few extra kilos around the belly. Sometimes it runs in the family.
But HDL is a signal, not a goal in itself. In studies, raising it with a drug did not protect the heart: what counts is removing what pushes it down.
And a very high HDL does not mean better protected arteries. For heart risk, LDL and ApoB matter more.
That is why it is read together with other tests:
- LDL cholesterol: The cholesterol that can build up in your arteries
- Triglycerides: Often high when HDL is low
- Total cholesterol: The sum, and its ratio to HDL
- ApoB: Counts the particles that can build up in your arteries
Normal HDL cholesterol levels by age and sex
For HDL the lab only sets a lower limit: below it, the result is marked low. On some reports the limit is 35 mg/dL for everyone.
Many labs, though, use a higher limit for women, and sometimes for men too. The one printed on your own report is the one that counts: if it marks your result low, go by your report.
In adults the limit usually does not change with age. It differs more between women and men: women usually have higher HDL.
In the Rosa report you also see your optimal range, which differs for women and men, and your HDL read together with your other blood fats.
What your result means
Find the row for your result, in mg/dL. A low HDL is not an immediate danger: it matters for your heart over the years. A result below 8, which is very rare, should always be seen by a doctor.
- Below 8: Extremely low. This is very rare. It can come from an inherited condition. Talk to a doctor.
- 8 up to your report’s limit, On some reports 8 to 35: Low. It often comes with high triglycerides, belly fat, smoking or too little exercise. Sometimes it runs in the family. Read it with your triglycerides and talk to your doctor, especially if it is very low.
- From your report’s limit up, On some reports above 35, For women the limit is often higher: Normal. Usually fine. But a very high HDL does not protect you more. In the Rosa report you also see whether you are in your optimal range.
If your HDL is low or high
- Low HDL cholesterol: It often comes with high triglycerides, belly fat, smoking or too little exercise.
- High HDL cholesterol: Usually not a problem, but very high does not protect you more. It can come from your genes or from alcohol.
High HDL cholesterol: is higher always better?
No. Up to a point, a higher HDL is linked to a lower risk for your heart. Beyond that, it does not protect you more: in studies, very high levels were sometimes linked to more health problems, not fewer.
A very high HDL can come from your genes or from alcohol. It causes no symptoms and does not need lowering, but it is no guarantee: LDL, ApoB and triglycerides give the real picture.
There are no foods to avoid. But if you drink often, drinking less is good for you, even if your HDL drops a little.
What can skew the result
A few things change the number for a while. It helps to know them before you read it.
- A recent illness: An infection with fever, surgery or a hospital stay can lower it for a while. Repeat the test once you are well.
- Steroids and testosterone: At high doses, as used in gyms, they push it down a lot. Tell your doctor.
- High-dose zinc: Taken as a supplement for a long time, it can lower it a little.
- Pregnancy: In pregnancy all blood fats rise. The result should be read with your obstetrician.
When to worry
Talk to a doctor if:
- Your HDL is below 8.
- It is very low and you do not know why.
- It is low and your triglycerides or glucose are high too.
- It has dropped a lot from one test to the next for no clear reason.
- You take testosterone or anabolic steroids.
- You have chest pain or pressure: call 112 or go to the emergency department.
With Rosa, an HDL below 8 is always flagged to a doctor. It is a very rare result.
Frequently asked questions
What is the LDL to HDL ratio? It is your LDL cholesterol divided by your HDL, and usually the lower it is, the better. It is read like the total to HDL ratio: your doctor looks at it with ApoB, blood pressure and smoking.
Do normal values change with age? In adults the limit on your report usually does not. It differs more between women and men: women usually have higher HDL, and many labs use a higher limit for them. Children and teenagers have different reference values.
Do I need to fast for an HDL cholesterol test? For HDL itself, no: a meal changes it very little. But it is measured together with triglycerides, which rise after a meal, so it is best to arrive fasted. You can drink water.
Is HDL cholesterol calculated? No, it is measured in your blood. It is LDL that is often calculated, from total cholesterol, HDL and triglycerides.
How often should it be checked? For people who feel well there is no fixed rule: Rosa measures it twice a year. If it is low and you change your habits, it is usually checked again after about three months.
Sources
- Madsen and colleagues, extreme high HDL cholesterol is paradoxically associated with high mortality in men and women: two population cohorts. European Heart Journal, 2017. PMID 28419274
- Nordestgaard and colleagues, fasting is not routinely required for a lipid profile: a joint consensus statement from EAS and EFLM. European Heart Journal, 2016. PMID 27122601
- Keene and colleagues, HDL-raising drugs (niacin, fibrates, CETP inhibitors) and heart risk: a meta-analysis of randomised trials. BMJ, 2014. PMID 25038074
- Kodama and colleagues, effect of aerobic exercise training on HDL cholesterol: a meta-analysis. Archives of Internal Medicine, 2007. PMID 17533202
- Smit and colleagues, blood pressure, blood fats and haematocrit during and after anabolic steroid use: a prospective study. Andrologia, 2022. PMID 35014715