Low red blood cells: causes and when to worry
With low red blood cells, haemoglobin is often low too: that is called anaemia. The most common cause is a lack of iron, but vitamin B12 or folate can be short too, or there may be blood loss. In pregnancy the count normally drops a little, because the blood gets more diluted.
What low red blood cells mean
It means there are fewer red cells in your blood than usual, so fewer cells to carry oxygen.
Haemoglobin is often low too: that is called anaemia. But it is haemoglobin that shows how marked it is, not the red cell count.
If your haemoglobin is normal and your red cells are just below the limit, it is usually nothing to worry about. Checking your ferritin and MCV as well may be enough.
What causes low red blood cells
They are the same as the causes of anaemia. The first is the most common.
- Too little iron: From heavy periods, a pregnancy, frequent blood donation or too little iron on your plate. Without iron the bone marrow makes fewer red cells, and smaller ones.
- Blood loss: Small hidden losses, for example from the gut. In men and after menopause, they are the first thing doctors look for.
- Too little B12 or folate: Your body needs them to make red cells. In this case there are fewer red cells, but they are bigger than normal.
- Long-lasting inflammation: A disease that has lasted a long time slows the bone marrow, which makes fewer red cells.
- Kidneys that filter less: Your kidneys give the bone marrow the signal to make red cells. When they work less, fewer red cells are made.
- More diluted blood: In pregnancy, or with a lot of endurance sport, the liquid part of the blood grows and the number drops, even without real anaemia.
Symptoms
If the drop is small, often none. When there is anaemia, you may notice:
- Tiredness that does not go away
- Shortness of breath when you exert yourself
- Pale skin
- Dizziness
- A racing heartbeat
- Cold hands and feet
These symptoms can have other causes too. And when anaemia comes on slowly the body adapts, so you can feel fine even with low numbers.
Low red blood cells in pregnancy
A small drop is usually normal. In pregnancy your blood volume grows, and the liquid part grows more than the red cells. So the count drops, especially from the second trimester on.
But pregnancy also needs a lot more iron, and a shortage is common. That is why your obstetrician checks your haemoglobin and, if needed, your ferritin, and decides whether you need a supplement.
If you feel very tired, short of breath or dizzy, tell your obstetrician.
Which tests to read alongside them
These tests help show whether there is anaemia and where it comes from.
What your result means
The lower end of the scale, in x10¹²/L. If they are low, check your haemoglobin too.
- Below your report’s limit, Women: usually below 4, Men: usually below 4.6: Low. Your haemoglobin is often low too, and then it is called anaemia. Sometimes the blood is just more diluted. Check your haemoglobin: if it is low too, talk to your doctor, the same day if it is below 8 g/dL.
- Within your report’s limits, Women: usually 4 to 5.2, Men: usually 4.6 to 5.6: Normal. Usually fine, but the number alone says little. Check your haemoglobin and MCV too. In the Rosa report you also see whether you are in your optimal range.
What to do if they are low
First find the cause, because the treatment depends on it. Where to start:
- Show your report to your doctor, who reads red cells together with haemoglobin, ferritin and MCV.
- Do not take iron without checking your ferritin first: if you are not short of iron, it does not help.
- If there is anaemia from a lack of iron, food alone is usually not enough. You need a supplement, with the dose and length set by your doctor. With a normal haemoglobin you usually start with food.
- Iron tablets often make stools dark. If they are black like tar, or you feel weak or dizzy, call 112 or go to the emergency department.
- What to eat: iron from red meat, fish and shellfish is absorbed best. Legumes and leafy greens have iron too: eat them with citrus or kiwi, and keep tea and coffee away from meals.
- Vitamin B12 comes from animal foods: if you do not eat them, talk to your doctor.
- If you gave blood recently, the count usually recovers on its own over the following months.
When to worry
Talk to your doctor if:
- Your haemoglobin is below your report’s limit, even slightly.
- You are a man, or a woman after menopause, and you are short of iron.
- You do not know why they are low, or they drop from one test to the next.
- Your haemoglobin is below 8 g/dL: see a doctor the same day.
- You see black stools or blood in your stools: call 112 or go to the emergency department.
- You are short of breath at rest, have chest pain or feel faint: call 112 or go to the emergency department.
With Rosa, a haemoglobin below 11 g/dL is always flagged to a doctor, below 8 urgently.
Frequently asked questions
Low red blood cells: when should I worry? Talk to your doctor if your haemoglobin is low too, or the cause is not known. With a haemoglobin below 8 g/dL, see a doctor the same day. With black stools or blood in your stools, shortness of breath at rest, chest pain or fainting, call 112 or go to the emergency department.
Can low red blood cells be a sign of cancer? Usually not: the most common causes are too little iron, heavy periods or a pregnancy. In men and after menopause, if iron is short, doctors look first for blood loss from the stomach or gut. Sometimes that comes from a tumour, which is why anaemia should be checked by a doctor.
How can I raise my red blood cells? By treating the cause, which is why the tests come first. If there is anaemia from too little iron, you usually need a supplement set by your doctor, and food helps keep your store up. If vitamin B12 or folate is short, your doctor gives you that instead.
Low red blood cells in older people: is it normal? They become more common with age, but age alone usually does not explain them. Your doctor looks for the cause, such as too little iron, too little vitamin B12 or kidneys that filter less.
Do athletes have lower red blood cells? Sometimes, slightly: with a lot of endurance sport the liquid part of the blood grows and the count is diluted. But iron can be short too: ferritin helps tell.
Sources
- British Society for Haematology, guideline for the diagnosis and management of polycythaemia vera. British Journal of Haematology, 2019. PMID 30478826
- British Society for Haematology, guideline for specific situations in polycythaemia vera and for raised red cells from other causes. British Journal of Haematology, 2019. PMID 30426472
- British Society of Gastroenterology, guidelines for iron deficiency anaemia in adults. Gut, 2021. PMID 34497146
- Dell’Edera and colleagues, beta thalassaemia carriers among couples planning a pregnancy in Italy. Journal of Maternal-Fetal and Neonatal Medicine, 2013. PMID 23039078
- Kiss and colleagues, oral iron after blood donation and how long haemoglobin takes to recover. JAMA, 2015. PMID 25668261