TSH: what it is, what it tells you and why we test it
TSH is the hormone your pituitary gland, at the base of your brain, uses to tell your thyroid to work harder or less. It works like a seesaw: when your thyroid works too little, TSH rises; when it works too hard, TSH falls. It is the first test for checking your thyroid.
Why we test it
Your thyroid is a small gland at the base of your neck. Its hormones set how fast your body works: heartbeat, temperature, energy, weight.
TSH moves before the thyroid hormones do. That is why it is the first test for your thyroid, and it often spots a problem before any symptoms.
Thyroid problems are common, especially in women, and they often come on slowly. A blood test can find them early.
What it tells you, and what it does not
TSH works the other way round: if it is high, your thyroid is usually working too little. If it is low, it is usually working too hard.
On its own, though, it does not make a diagnosis. Your doctor can ask for FT4, the free thyroid hormone in your blood, and sometimes for thyroid antibodies.
And if your TSH is normal but tiredness or weight gain will not shift, the cause is usually something else: talk to your doctor.
In the Rosa panel, these tests help read it:
- LDL cholesterol: A slow thyroid can push it up
- Haemoglobin: If it is low, tiredness may have another cause
- Ferritin: Low iron can feel like a slow thyroid
- Vitamin B12: Too little B12 can also make you tired
Normal TSH levels
The lab decides what is normal. It is usually 0.4 to 4 mIU/L. Your own report may print slightly different limits.
Some reports write the unit as µIU/mL: it is the same unit, and the numbers do not change.
The limit is the same for women and men. With age TSH tends to rise a little, and in pregnancy the limits change.
In the Rosa report you see your TSH next to the rest of the panel, read together with your other tests.
What your result means
Find the row for your result, in mIU/L. TSH alone does not make a diagnosis: your doctor reads it with your symptoms and, if needed, with FT4, which they can ask for.
- Below your report’s limit, On a typical report below 0.4: Low. It can mean a thyroid that works too hard. Sometimes medicines, pregnancy or biotin are behind it. Talk to your doctor, who can ask for FT4 and, if needed, thyroid antibodies.
- Within your report’s limits, On a typical report 0.4 to 4: Normal. Your thyroid is usually working as it should. In the Rosa report you find it explained together with the rest.
- Above your report’s limit, On a typical report above 4: High. It can mean a thyroid that works too little. Often it is only slightly above. Talk to your doctor: they usually repeat it and ask for FT4 and thyroid antibodies.
If your TSH is high or low
- High TSH: Your thyroid is usually working a little less. Often it is only slightly above, and it gets checked again.
- Low TSH: Your thyroid is usually working a little harder. Sometimes medicines, pregnancy or biotin are behind it.
What causes high TSH
If TSH is high but FT4 is normal, it is called subclinical hypothyroidism: your thyroid is struggling a little but still coping. Often no treatment is needed, and your doctor checks it again over time. If you are pregnant or trying for a baby, it is different.
- Hashimoto’s thyroiditis: The immune system slowly attacks the thyroid. It is a common cause, more frequent in women. Antibodies, which your doctor can ask for, show it.
- Age: TSH tends to rise a little over the years. In an older person, a value just above the limit can be normal.
- A dose to review: If you already take thyroid hormone, you may need a different dose. Do not change it on your own: talk to your doctor.
- Some medicines: Lithium, a mood medicine, and amiodarone, a heart medicine, can push it up. Bring your doctor the list of what you take.
- Too much iodine: For example from seaweed supplements. Tell your doctor.
- Thyroid surgery or treatment: After surgery or radioactive iodine treatment, the thyroid can work less.
Symptoms of high and low TSH
Often none, especially when the value is only slightly out of range. When there are symptoms, they come on slowly:
- High TSH, slow thyroid (hypothyroidism): tiredness, feeling cold, dry skin, constipation, a few extra kilos.
- Low TSH, fast thyroid (hyperthyroidism): a pounding or racing heart, weight loss, feeling hot and sweaty, shaky hands, nervousness, poor sleep.
These symptoms are common and have many other causes. TSH helps show whether your thyroid is involved.
Low TSH: what it can mean
It usually means there is a lot of thyroid hormone in your blood, so the pituitary turns its signal down. In people who take thyroid hormone, a dose that is a little high is often the reason. In others, the thyroid may be working too hard: this is called hyperthyroidism.
But it is not always a problem. In early pregnancy it normally drops, and biotin can make it read lower than it is. If you take thyroid hormone, do not change the dose on your own.
Your doctor usually asks for FT4 and, if needed, other tests. If TSH is only slightly low and FT4 is normal, your doctor often checks it again before deciding.
What can skew the result
A few things change the number for a while. It helps to know them before you read it.
- Biotin: It is in many hair and nail supplements and can make TSH read lower than it is. Ask your doctor whether to stop it at least two days before the blood test.
- The time of the test: TSH is higher at night and early in the morning, lower in the afternoon. To compare two tests, have them at the same time of day.
- An illness: A serious infection or a hospital stay can shift it even with a healthy thyroid. Your doctor usually checks it again once you are well.
- Pregnancy: In the first months TSH usually drops, and that is normal. Pregnancy has its own limits: ask your obstetrician.
When to worry
Talk to your doctor if:
- Your TSH is outside your report’s limits, even slightly: your doctor will usually repeat it and ask for FT4.
- You are pregnant or trying for a baby: show it to your gynaecologist or obstetrician too.
- Your heart pounds or races, you lose weight for no reason or your hands shake.
- Tiredness, feeling cold and dry skin do not go away, or you notice a swelling at the base of your neck.
- You already take a thyroid medicine and the value has changed: do not change the dose on your own.
- Your heart races with chest pain, sudden breathlessness or fainting: call 112 or go to the emergency department.
Frequently asked questions
What is TSH? Thyroid-stimulating hormone, also called thyrotropin: the hormone that stimulates your thyroid. It is made by the pituitary, a small gland at the base of your brain.
Does the normal range for TSH change with age? The limit on your report usually does not. But TSH tends to rise a little with age, even with a healthy thyroid. In an older person a value just above the limit can be normal: your doctor weighs it.
TSH in pregnancy: what changes? In pregnancy the thyroid has to work harder and the limits are different. In the first months TSH usually drops. If you are pregnant or trying for a baby, show your result to your gynaecologist or obstetrician.
Can biotin skew TSH? Yes. High-dose biotin, the kind in hair, skin and nail supplements, can make it read lower than it is. If you take it, ask your doctor whether to stop it at least two days before the blood test, and tell the lab.
How often should it be checked? For people who feel well there is no fixed rule: Rosa measures it once a year. If it is slightly high, your doctor usually repeats it after two or three months, together with FT4.
Sources
- Pearce and colleagues, ETA guideline on the management of subclinical hypothyroidism, a mildly raised TSH with a normal FT4. European Thyroid Journal, 2013. PMID 24783053
- Bekkering and colleagues, clinical practice guideline on thyroid hormone treatment for subclinical hypothyroidism. BMJ, 2019. PMID 31088853
- Ehrenkranz and colleagues, how TSH varies with the time of day, age and sex. Thyroid, 2015. PMID 26061389
- Li and colleagues, biotin supplements and the hormone tests they can skew, in healthy adults. JAMA, 2017. PMID 28973622
- Alexander and colleagues, ATA guidelines on thyroid disease in pregnancy and after birth. Thyroid, 2017. PMID 28056690